Compaction and folding in model proteins

نویسندگان

  • Ting-Lan Chiu
  • Richard A. Goldstein
چکیده

Protein folding is modeled as diffusion on a free-energy landscape, allowing use of the diffusion equation to study the impact of energetic parameters on the folding dynamics. The free-energy landscape is characterized by two different order parameters, one representing the degree of compactness, the other a measure of the progress towards the folded state. For marginally stable proteins, fastest folding is achieved when the nonspecific interactions favoring compaction are strong, resulting in a high folding temperature. Such proteins fold by rapid collapse followed by slower accumulation of correct contacts. © 1997 American Institute of Physics. S0021-9606 97 50435-1

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تاریخ انتشار 1997